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Type A, Asian Strain, as Studied by Light and Electron Microscopic Examination of Bronchoscopic Biopsies

JOHN J. WALSH, M.D.; LAWRENCE F. DIETLEIN, M.D.; FRANK N. LOW, Ph.D.; GEORGE E. BURCH, M.D.; WILLIAM J. MOGABGAB, M.D.

Arch Intern Med. 1961;108(3):376-388.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In contrast to the ubiquity of human influenzal infection, documentation of the accompanying characteristic histopathologic alterations is limited. This is largely due to the generally nonfatal course of influenza in man. Further difficulties arise from the almost constant presence of complicating bacterial infection in fatal cases. Such circumstances are indeed unfortunate in the light of current limitations in the prevention and treatment of influenza. For these reasons, a major objective of our multidisciplinary investigation^1-3 of pandemic influenza (Type A, Asian Strain) was the histologic study of the tracheobronchial tree in influenza uncomplicated by bacterial infection. To our knowledge this is the first description as studied by bronchoscopic biopsy of the mucosal response in humans to uncomplicated influenza.

Material and Methods

Initially, bronchoscopy and tracheobronchial mucosal biopsy were performed from 1 to 7 days after the acute onset of symptoms in 12 young adults with apparent uncomplicated influenza. Subsequent studies . . . [Full Text PDF of this Article]

Author Affiliations
NEW ORLEANS

From the Department of Medicine, Tulane University School of Medicine, the Department of Anatomy, Louisiana State University School of Medicine, the Charity Hospital of Louisiana at New Orleans, and the U.S. Public Health Service Research Laboratory, New Orleans.

Footnotes
Submitted for publication Sept. 6, 1960.

Aided in part by grants from the Public Health Service and the Upjohn Co., Kalamazoo, Mich.

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