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SIMEON LOCKE, M.D.; JOHN P. MERRILL, M.D.; H. RICHARD TYLER, M.D.

Arch Intern Med. 1961;108(4):519-530.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Attempts to evaluate the effects of uremia on the nervous system must separate those aspects secondary to the uremia from those attributable to the underlying disorder. Many diseases which affect the kidneys also directly affect the nervous system. In an attempt to distinguish the effects of uremia on the nervous system, a series of patients with acute uremia was studied. Cases of lupus erythematosus, sclerodema, polyarteritis nodosa, multiple myeloma, polycystic disease, and severe hypertension with renal involvement were excluded from consideration. Included in the category of acute renal failure were all cases in which there was no evidence of renal disease antedating the present illness and in which an acute insult could be postulated.

Thirteen consecutive patients with acute anuria were seen in neurological consultation after admission to the Peter Bent Brigham Hospital. They were examined daily until discharged or until death. Specific attention was directed to the mental . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

Department of Neurology, Harvard Medical School and the Medical Service of the Peter Bent Brigham Hospital.; Instructor in Neurology, Harvard Medical School, Associate in Medicine, Peter Bent Brigham Hospital, Assisting Physician in Neurology, Boston City Hospital (Dr. Locke); Assistant Professor in Medicine, Harvard Medical School, Senior Associate in Medicine, Peter Bent Brigham Hospital, Investigator, Howard Hughes Medical Institute (Dr. Merrill); Instructor in Neurology, Harvard Medical School, Senior Associate in Medicine, Peter Bent Brigham Hospital, Investigator, Howard Hughes Medical Institute (Dr. Tyler).

Footnotes
Submitted for publication April 13, 1960.

This work was assisted by U.S. Public Health Grant B1290(C3) and the Mary Kuhn Cancer Research Fund.

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