This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

JAMES E. DOHERTY, M.D.; WILLIAM H. PERKINS, M.D.; GEORGE K. MITCHELL, M.D.

Arch Intern Med. 1961;108(4):531-539.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A number of publications have appeared in recent years regarding the metabolic behavior, fate, and excretion of C¹⁴-labeled digitoxin.^1-8 Labeled digoxin has received little attention.^9-11 The preparation of a C¹⁴-labeled compound has not been practical because of the expense and uncertainty of the digoxin content of digitalis glycosides.

The possibility of a tritium (H³) label was explored and was found to be both cheap and practical utilizing the Wilzbach hydrogen exchange method. The present study was undertaken to study the serum levels, absorption, and excretion of tritium-labeled digoxin^* in human subjects after singledose oral digitalization.

Most of the metabolic studies of unlabeled digoxin^12,13 have revealed the presence of unchanged digoxin and metabolite "B" in the urine of both rats and humans. Brown and Wright₁₄ reported the presence of metabolite "F" in the tissue of rats. Metabolite "B" has not been demonstrated . . . [Full Text PDF of this Article]

Author Affiliations
LITTLE ROCK, ARK.

From Medical and Radioisotope Services, Veterans Administration Consolidated Hospital, and University of Arkansas Medical Center, Little Rock.; Cardiologist, Veterans Administration Consolidated Hospital, and Assistant Professor of Medicine, University of Arkansas Medical Center (Dr. Doherty); Chief, Radioisotope Service, Veterans Administration Consolidated Hospital, and Assistant Professor of Medicine, University of Arkansas Medical Center (Dr. Perkins); Instructor in Medicine, University of Arkansas Medical Center (Dr. Mitchell).

Footnotes
Submitted for publication Oct. 28, 1960.

With the technical assistance of Carolyn Dodd, M.T. (ASCP).

Supported in part by a grant from Burroughs Wellcome & Co., Inc.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?