This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (10)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

2,6-Dimethoxyphenyl Penicillin; Penicillin X-1497

ARTHUR WHITE, M.D.; DONALD T. VARGA, M.D.

Arch Intern Med. 1961;108(5):671-678.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Several British investigators have published preliminary observations with a new penicillin which is active against penicillin-ase-producing staphylococci.^1-10

Our studies of this penicillin, sodium methicillin (penicillin X-1497 or sodium 2,6-dimethoxyphenyl penicillin monohydrate), have included comparisons of the bacteriostatic and bactericidal activities of methicillin, penicillin G, penicillin V, and phenethicillin (penicillin 152) against several recently isolated bacterial species; the susceptibility tests of staphylococci were correlated with the activity of staphylococcal penicillinase on 3 penicillins.

In addition, measurements were made of the antistaphylococcal activity of serum and transudates after large intramuscular doses of methicillin.

A number of hospitalized patients have been treated to determine the effect of methicillin on nasal carriers of staphylococci. Finally, a small group of patients with serious bacterial infections have been treated and observed for toxicity and therapeutic effectiveness.

Materials and Methods

The susceptibility of various bacteria to the 4 penicillins^* was determined by a twofold serial . . . [Full Text PDF of this Article]

Author Affiliations
LOUISVILLE, KY.

From the Department of Medicine, University of Louisville, School of Medicine.; Assistant Professor of Medicine (Dr. White); Assistant Resident in Medicine (Dr. Varga).

Footnotes
Submitted for publication Nov. 11, 1960.

Presented in part at a symposium on Synthetic Penicillins at Syracuse, N.Y., Sept. 7, 1960, and published as proceedings of the conference by Syracuse University Press. Supported by grants from Bristol Laboratories, Syracuse, N.Y., and from the National Institutes of Allergy and Infectious Disease (E-2561), Bethesda, Md.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?