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J. M. B. BLOODWORTH, JR., M.D.

Arch Intern Med. 1961;108(5):695-701.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

One of the first pathologic changes described in the diabetic patient was an enlarged, fatty liver.¹ Since that time, numerous studies have indicated that a fatty liver is present in from 15% to 50% of diabetic patients.^2,3 Laboratory evidence of liver dysfunction is present in a significant percentage of diabetic patients.^3-5

Fatty metamorphosis of the liver is an integral part of the pathologic picture in the majority of cases of cirrhosis of the liver.⁶ Many investigators have stated that if a fatty liver from any cause persists, cirrhosis will develop.⁷ Chaikoff and Connor reported that the production of a fatty liver in the dog by a high-fat diet will ultimately lead to cirrhosis of the liver.⁸ Pancreatectomized dogs maintained on insulin develop a fatty liver and ultimately show cirrhosis of the liver.⁹

Despite these facts, a direct relationship between diabetes mellitus and cirrhosis . . . [Full Text PDF of this Article]

Author Affiliations
COLUMBUS, OHIO

Professor of Pathology, The Ohio State University.

Footnotes
Submitted for publication Dec. 5, 1960.

Supported in part by Grant No. 1173 from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health.

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