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ROBERT D. LANGE, M.D.; JOHN M. McCARTHY, M.D.; NEIL I. GALLAGHER, M.D.

Arch Intern Med. 1961;108(6):850-858.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Red blood cell production is regulated in part by a specific humoral factor, erythropoietin.^1-5 Although the physiologic properties of this substance have been studied extensively, the relationship of erythropoietin to clinical disease remains speculative.^6-12 This paper reports the results of an assessment of plasma and urine erythropoietin levels in 16 patients with acute or chronic bone marrow failure. In 1 patient serial studies were undertaken during the development of a fortuitous remission, while in another, plasma and urinary erythropoietin levels were compared in simultaneously collected samples.

Methods and Material

Sixteen patients with marrow failure were studied. Twelve were hospitalized at the St. Louis Veterans Administration Hospital, the remainder at the Barnes and Jewish Hospitals.^* In 13 patients the disorder was chronic. The diagnosis in 4 patients was chronic bone marrow failure with erythroid hyperplasia; in 5, chronic bone marrow failure with erythroid hypoplasia; in 1, congenital erythroid hypoplasia; . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the St. Louis Veterans Administration Hospital and the Departments of Medicine of Washington University and St. Louis University.

Footnotes
Submitted for publication July 5, 1961.

Supported in part by U.S. Public Health Service Grant No. H-2793.

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