This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (28)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

WILLIAM L. GREEN, M.D.; SIDNEY H. INGBAR, M.D.

Arch Intern Med. 1961;108(6):945-952.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Most patients with pituitary hypofunction have evidence of multiple target gland insufficiency arising from a destructive lesion in or near the sella turcica. Some patients with extensive pituitary destruction, however, exhibit hypogonadism as the only clinically evident defect; if the disease progresses, failure of thyroid and adrenal function later becomes apparent. Thus, it has been postulated and confirmed in animal experiments¹ that a lesser degree of pituitary destruction is necessary to affect gonadal function than to affect the function of the thyroid gland and adrenal cortex.

Investigation of the functional consequences of pituitary lesions in man, however, has been handicapped by the lack of procedures to test the pituitary's reserve capacity to secrete its several hormones. Recently, a delicate test of adrenocorticotrophic hormone (corticotropin; ACTH) reserve has been described, employing 1,2-bis-(3 pyridyl)-2-methyl-1-propanone (SU-4885), an inhibitor of adrenal 11-β-hydroxylase.² This drug blocks the formation of the adrenal end-products, especially . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School.; Research Fellow in Medicine, Harvard Medical School; Research Fellow in Medicine, Thorndike Memorial Laboratory; National Institutes of Health, Post-Doctoral Research Fellow (Dr. Green); Investigator, Howard Hughes Medical Institute (Dr. Ingbar).

Footnotes
Submitted for publication Nov. 23, 1960.

This investigation was supported in part by research grant No. A-267 from the National Institute of Arthritis and Metabolic Diseases of the National Institutions of Health, Public Health Service, and in part by the Medical Research and Development Board, Office of the Surgeon General, Department of the Army, under Contract No. DA-49-007-MD-412.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?