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Report of Case and Review of the Literature

ANDREW G. ENGEL, M.D.; J. M. STICKNEY, M.D.

Arch Intern Med. 1962;109(2):168-175.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The evolution of one myeloproliferative disorder into another is not unusual.^1,2 Thus, polycythemia vera, myeloid metaplasia, and myelocytic leukemia may follow, or imperceptibly merge into, one another.

Pernicious anemia may also be followed by myelocytic leukemia, and the incidence of myelocytic leukemia in the relatives of patients with pernicious anemia has been reported to be higher than it is in the general population.³ On the other hand, myeloid metaplasia or polycythemia vera occurring in proved cases of pernicious anemia is distinctly uncommon.

The present report concerns a patient who developed polycythemia vera following therapy for pernicious anemia, relapsed into pernicious anemia 6 years after the onset of polycythemia vera, and again became polycythemic after 9 months of vitamin B₁₂ therapy.

Report of Case

A 62-year-old white woman who was first seen at the Mayo Clinic in January, 1960, complained of severe fatigue, loss of appetite, and a loss . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN.

The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.; Fellow in Medicine, Mayo Foundation (Dr. Engel); Section of Medicine (Dr. Stickney), Mayo Clinic and Mayo Foundation.

Footnotes
Submitted for publication Nov. 15, 1960.

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