This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (25)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

RICHARD B. DAVIS, M.D.; B. J. KENNEDY, M.D.

Arch Intern Med. 1962;109(2):192-200.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is now recognized that there is considerable variation in the clinical manifestations,^1,2 the origin, and character of metastatic carcinoid tumors. A malabsorption syndrome³ and scleroderma⁴ may accompany the carcinoid syndrome. This syndrome may be produced by bronchial carcinoids with metastases,^5-8 oat-cell carcinoma,⁹ argentaffinoma of the lung without hepatic metastases,¹⁰ and pancreatic carcinoma with demonstrated 5-hydroxytryptophan decarboxylase activity.¹¹ The syndrome is apparent in only 20% of patients with carcinoid tumors and hepatic metastases¹² and may rarely be associated with normal levels of 5-hydroxyindoleacetic acid (5-HIAA) excretion in the urine.^13,14

The possible association of carcinoid syndrome and Cushing's syndrome has been suggested by the report of Harrison¹⁵ of a patient with bronchial carcinoma and clinical features of adrenal hyperplasia. In their patient 17-ketosteroid excretion was normal and 5-HIAA excretion in the urine was moderately increased as shown by paper chromatography. . . . [Full Text PDF of this Article]

Author Affiliations
MINNEAPOLIS

From the Department of Medicine, University of Minnesota Medical School and University Hospitals: Instructor (Dr. Davis); Associate Professor of Medicine (Dr. Kennedy).

Footnotes
Submitted for publication Jan. 14, 1961.

This investigation was supported by a research grant (CY 3143) from the National Cancer Institute of the National Institutes of Health and by the Minnesota Division of the American Cancer Society.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?