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Report of a Case with Recovery Following the Use of Vaccinia Immune Globulin

F. ROBERT FEKETY, JR., M.D.; STEPHEN E. MALAWISTA, M.D.; DAVID L. YOUNG, M.D.

Arch Intern Med. 1962;109(2):205-208.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since a successful smallpox vaccination is in a sense an iatrogenic disease, it is particularly unfortunate that patients with chronic lymphatic leukemia may develop a progressive necrotizing vaccinial infection (vaccinia gangrenosa) following this procedure. In the past, this complication has invariably been fatal.³ This is the report of an adult with chronic lymphatic leukemia who recovered from vaccinia gangrenosa with the aid of vaccinia immune globulin.

Report of Case

A 66 year old white retired postal worker was admitted to the hospital on June 22, 1959, because of weakness of 3 days' duration. He had been found to have chronic lymphatic leukemia in 1956 and had been treated with radiation and chlorambucil. One month before admission his hematocrit was 37%. He felt well until a few days before admission, taking chlorambucil, 2 mg/day. In preparation for a trip abroad, he was vaccinated by his private physician on June 17. . . . [Full Text PDF of this Article]

Author Affiliations
WEST HAVEN, CONN.

From the Medical Service, Veterans Administration Hospital, West Haven, Conn., and the Department of Medicine, Yale University School of Medicine, New Haven, Conn.; Formerly Resident in Medicine, Veterans Administration Hospital, West Haven, Conn., presently Instructor in Medicine, the Johns Hopkins University School of Medicine, Baltimore (Dr. Fekety); formerly Assistant Resident in Medicine, presently Clinical Associate, National Institutes of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md. (Dr. Malawista); formerly Assistant Resident in Medicine, presently Assistant Resident in Medicine, Parkland Memorial Hospital, Dallas, Texas (Dr. Young).

Footnotes
Submitted for publication Dec. 29, 1960.

Supported in part by a Public Health Service Training Grant (2E-9), National Institutes of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Md.

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