This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (16)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

NORBERT FREINKEL, M.D.; CHARLES J. GOODNER, M.D.

Arch Intern Med. 1962;109(2):235-244.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

During pregnancy, a new structure, the conceptus, arises de novo, grows, ages, and is ultimately expelled. In the maternal host, these awesome phenomena are accompanied by major metabolic alterations. It is the purpose of the present communication to focus upon one aspect, namely, the changes in maternal carbohydrate metabolism, and to summarize recent investigations concerning the possible role of the conceptus in their development.

The Problem

For the human female, pregnancy constitutes a form of diabetogenic challenge.^* Although the disposition of intravenously administered glucose is normal,³ the decline in blood sugar following standard doses of exogenous insulin is subnormal.⁴ The dichotomy would suggest that preservation of normal glucose tolerance during pregnancy necessitates an enhanced secretion of endogenous insulin. This premise is supported by the gestational changes in the histology of the pancreatic islet cells.^5,6 It is further reinforced by the clinical experience in subjects with marginal or . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

Investigator, Howard Hughes Medical Institute (Dr. Freinkel).; Formerly Public Health Service Research Fellow of the National Institute of Arthritis and Metabolic Diseases, U.S. Public Health Service (Dr. Goodner).; Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School.

Footnotes
Submitted for publication Oct. 4, 1961.

This work was supported in part by Research Grant A-1571 and Training Grant 2 A-5060 from the National Institute of Arthritis and Metabolic Diseases, U.S. Public Health Service.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?