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BERENDSOHN S. SIEGFRIED, M.D.

Arch Intern Med. 1962;109(3):256-264.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Man living at high altitudes is constantly subjected to a stress, caused by the low oxygen tension in the air he breathes, which brings into play a series of mechanisms that permit him to adapt to his environment. This is the phenomenon of acclimatization to altitude,¹ in which lowered saturation of the arterial blood, resulting from the reduced partial pressure of oxygen, stimulates the hematopoietic system to produce the well-known polycythemia of high altitude.²

The chronic hypoxia affects not only the hematopoietic system, but other organs and systems as well.^3,4 The liver, site of control of many intermediate metabolic processes, consumes more oxygen than most other organs, so that anoxia, of any origin, may cause definite changes in its function⁵ and structure.⁶ In addition, functional alterations in other systems, caused by hypoxia, may affect liver function.⁷

Studies of hepatic function in acute hypoxia⁸ . . . [Full Text PDF of this Article]

Author Affiliations
LIMA, PERU

From the Institute of Andean Biology and the Department of Pathological Physiology, Faculty of Medicine, Lima, Peru.

Footnotes
Submitted for publication Nov. 28, 1960.

Supported by the USAF, Contract 41(657)-249.

Present address: Department of Internal Medicine, University of Minnesota Hospitals, Minneapolis 14.

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