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Report of a Case with Bleeding, Perforation, and Survival Following Resection

EDWARD J. HEITZMAN, M.D.; GEORGE C. HEITZMAN, M.D.; CHARLES F. ELLIOTT, M.D.

Arch Intern Med. 1962;109(5):595-600.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Although primary amyloidosis has been recognized since the middle of the nineteenth century,¹ little clinical interest was evidenced until Lubarsch² reported 3 new cases in 1929. In 1935, Reimann, Kouchky, and Eklund³ presented the first case of primary amyloidosis diagnosed clinically. Since then, over 200 cases have been published. With the advent of these data, understanding of the protean manifestations of the disease has grown, and subsequently several classifications have been proposed. Probably the most widely accepted is that of Dahlin⁴:

1. Primary Amyloidosis
   
   1. Systemic
      
   2. Tumefactive
      
   
   
2. Amyloidosis complicating Myeloma
   
   1. Systemic
      
   2. Tumefactive
      
   
   
3. Secondary Amyloidosis
   
   1. Systemic
      
   2. Tumefactive One year after this classification was published, a further subdivision of primary amyloidosis was recognized—familial amyloidosis.⁵ Since then, over 108 cases have been reported and indicate a definite clinical pattern (neuropathy, gastrointestinal and cardiovascular involvement, and ocular manifestations) with a simple dominant
      
   
   

Author Affiliations
SYRACUSE, N.Y.

Associate Attending Physician, Department of Medicine (Dr. E. J. Heitzman), Assistant Attending Surgeon, Department of Thoracic Surgery (Dr. G. C. Heitzman), Resident in General Practice (Dr. Elliott), St. Joseph's Hospital, Syracuse.

Footnotes
Submitted for publication Jan. 14, 1961.

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