This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Case Report and Review of Literature

P. V. STRUMIA, M.D.; F. D. RAYMOND, M.D.

Arch Intern Med. 1962;109(5):603-608.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a recent report. Ley et al.¹ have described the occurrence of circulating antipenicillin antibodies in patients who had received penicillin therapy. These antibodies were demonstrated by agglutination of penicillin-coated red blood cells by their sera. No agglutination of the same cells not coated with penicillin occurred with the same sera. Agglutination took place both by the saline and indirect antiglobulin technique. Cells coated with other antibiotics were not agglutinated by these sera. Eluates from the agglutinated cells agglutinated the penicillinized cells as well. Inhibition of agglutination was found after addition of penicillin to these sera prior to mixing with the test cells, but no inhibition was noted by addition of other antibiotics.

Penicillin has been used extensively since the first clinical trials in this country in 1942. In several large series² approximately 1% to 8% of patients exhibited an allergic response to the drug, depending on the . . . [Full Text PDF of this Article]

Author Affiliations
BRYN MAWR, PA.

Laboratory of Clinical Pathology of The Bryn Mawr Hospital and The John S. Sharpe Research Foundation (Dr. Strumia); F. D. Raymond, M.D., Department of Medicine of The Bryn Mawr Hospital (Dr. Raymond).

Footnotes
Submitted for publication Jan. 25, 1961.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?