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DWIGHT J. HOTCHKISS, JR., M.D.; MATTHEW H. BLOCK, Ph.D., M.D.

Arch Intern Med. 1962;109(6):695-711.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

It has been known since 1903¹ that clinical and hematologic remissions in chronic myelogenous leukemia, a generalized disease, follow irradiation therapy localized to the spleen.^2,3 The white count will fall and the hemoglobin rises. It has also been apparent that the beneficial effects of irradiation persist for some time after the cessation of therapy.^4-5

In an attempt to understand this phenomenon, studies of the sternal bone marrow have been made in these patients following splenic irradiation. Early observers reported contradictory results.^5-9 In more recent work, a decrease in marrow granulocytic tissue¹⁰ and a decrease in the number of mitotic figures in the marrow¹¹ were observed following splenic irradiation. All of these studies, however, have short-comings in that (1) reliance was placed upon study of bone marrow smears which do not portray accurately the structure of the marrow,^12,13 and (2) patients were not . . . [Full Text PDF of this Article]

Author Affiliations
DENVER

University of Colorado Medical Center.; U.S. Public Health Service Trainee; at present: Associate in Medicine, Hunterdon Medical Center, Flemington, N.J., and Clinical Instructor in Medicine, New York University-Bellevue Medical Center, New York (Dr. Hotchkiss); Associate Professor of Medicine, University of Colorado Medical Center,- Denver (Dr. Block).

Footnotes
Submitted for publication June 26, 1961.

Presented in part at the 45th Annual Meeting of the Federation of American Societies for Experimental Biology, April 14, 1961.

Supported by the Leukemia Society, Inc., New York City and by the Institutional Cancer Research Grant of the American Cancer Society of the University of Colorado, known as the Lee Ann Harding Memorial Grant for Cancer Research.

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