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Case Untreated for Seventeen Years

EDWARD R. BURKA, M.D.

Arch Intern Med. 1962;109(6):717-723.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Diabetes insipidus is an infrequent syndrome due to a deficiency of the antidiuretic hormone (ADH) and secondary to malfunction of the hypothalamo-neurohypophyseal system. The observation that a lesion must destroy the supraoptic nuclei bilaterally or interrupt the nerve tracts connecting these nuclei with the neurohypophysis supports the contention that the hormone is produced in the hypothalamus and stored in the posterior pituitary.¹ ADH is released in response to osmoreceptors located in the hypothalamus, and it has been possible to differentiate the syndrome resulting from primary failure of the osmoreceptors from that due to a deficiency of the hormone itself.² Primary and secondary forms of the syndrome exist, and postmortem examination will demonstrate a lesion in the hypothalamo-neurohypophyseal system in a large percentage of cases. Granulomatous or metastatic infiltration is most commonly found.³ The primary or idiopathic form, which may occur on a hereditary basis, usually appears in . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

USPHS Fellow in Hematology, Presbyterian Hospital, New York. Formerly Regimental Surgeon, 504th Parachute Infantry Regiment.

Footnotes
Submitted for publication Feb. 8, 1961.

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