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JAMES H. BAXTER, M.D.

Arch Intern Med. 1962;109(6):742-757.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Among the striking manifestations of nephrosis or nephrotic syndrome are hyperlipidemia and lipemia, which are reflections of increased levels of certain classes of serum lipoproteins. Selected studies on the character and mechanisms of the hyperlipoproteinemia are summarized in this article. The physiologic and morphologic effects of the lipoprotein abnormality have been omitted from consideration, for lack of relevant data of a definitive nature. Recent observations in man are emphasized when available, but studies on the experimental disease in rats and dogs are also included. Normal serum lipoprotein classes and normal lipoprotein metabolism are described briefly as a background for the abnormal findings in nephrosis. Despite the continued interest of clinicians and physiologists and more recently chemists in the lipid derangement in nephrosis, very few questions concerning its origin can be considered settled.

State of Serum Lipids and Lipoproteins

Serum lipids under normal and pathologic conditions exist largely in combination with . . . [Full Text PDF of this Article]

Author Affiliations
BETHESDA, Md.

Laboratory of Cellular Physiology and Metabolism, National Heart Institute.

Footnotes
Submitted for publication Feb. 14, 1962.

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