This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

I. Effects on Blood Pressure of Bendroflumethiazide, Potassium Chloride, and Spironolactone

HANS G. GRIEBLE, M.D.; LOUIS C. JOHNSTON, M.D.

Arch Intern Med. 1962;110(1):26-33.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Pilot studies with bendroflumethiazide, a recently introduced benzothiadiazine diuretic,^1,2 suggested superior antihypertensive qualities. Long-term effects on outpatients were studied and compared to placebo, reserpine, and other benzothiadiazine derivatives. Our observations suggested that bendroflumethiazide, given singly, often proved unusually effective. We postulated a separate group of "diuretic sensitive" patients and a therapy-induced bimodal redistribution of blood pressure was sought. Blood pressure responsiveness was also statistically related to various other clinical parameters including dietary sodium intake. The depressor effect of low-potassium diets,³ the stimulation of aldosterone by potassium,^4,5 and the results of animal experiments^6,7 made it pertinent to test the blood pressure influence of potassium chloride supplementation. Overproduction of aldosterone, whatever its cause, might contribute to the refractoriness of high blood pressure to diuretic therapy. This prompted a trial of combination therapy of bendroflumethiazide with spironolactone in 17 patients with severe hypertension, inadequately controlled by bendroflumethiazide therapy alone. . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the University of Illinois Research and Educational Hospitals and the Department of Medicine, University of Illinois College of Medicine.

Footnotes
Submitted for publication Feb. 9, 1962.

The bendroflumethiazide used in this study was supplied as Naturetin by Dr. R. C. Merrill, E. R. Squibb and Sons, New Brunswick, N.J. The spironolactone used in this study was supplied as Aldactone by Dr. C. L. Gantt, G. D. Searle and Co., Chicago.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?