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A Therapeutic Trial

EZRA SOHAR, M.D.; JOSEPH GAFNI, M.D.; MOSHE CHAIMOW, M.D.; MORDECHAI PRASS, M.D.; HARRY HELLER, M.D.

Arch Intern Med. 1962;110(2):150-154.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Familial Mediterranean fever (FMF) is a genetic disorder with complete autosomal recessive inheritance. It is prevalent in peoples of Mediterranean stock, particularly Sephardi Jews and Armenians.^1,2 The disease is manifested by 2 independent phenotypic characters due to the same presumed inborn error of metabolism: (1) attacks of fever accompanied by pain in the abdomen, chest, skin or joints, usually appearing in childhood or adolescence and recurring at irregular intervals throughout life; (2) amyloidosis, causing death, at an early age, due to renal failure.³

The only factor which is known to have produced remission from attacks with a high degree of consistency is pregnancy.¹ Since no uniformly successful therapeutic measure has been made available to date, the report of Mellinkoff et al.⁴ as to the efficacy of low-fat diet in 8 cases is of special interest. A therapeutic trial in a large series of cases was embarked . . . [Full Text PDF of this Article]

Author Affiliations
TEL-AVIV, ISRAEL

Department of Medicine, Tel-Hashomer Hospital.

Footnotes
Submitted for publication Jan. 23, 1962.

This study was supported in part by Research Grant A-2857 from the U.S. Public Health Service, National Institutes of Health, Bethesda, Md.

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