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Comparative Antibiotic Activity of Serum During Repeated Doses

CALVIN M. KUNIN, M.D.

Arch Intern Med. 1962;110(2):166-169.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1957 McCormick et al.¹ published an account of a new family of tetracycline derivatives, the demethyltetracyclines. In 1958 Kunin and Finland² reported a comparative study of equal doses of tetracycline (TC) and demethylchlortetracycline (DMCT) in man in which they demonstrated quite clearly that DMCT was more active than TC against 3 test organisms (including a group A β-hemolytic streptococcus, a staphylococcus, as well as the customary organism used in tetracycline assays, Bacillus cereus) and produced significantly higher and more sustained anti-microbial levels by weight for each organism following oral ingestion. These studies were confirmed and extended by the reports of Sweeney et al.,³ Hirsch and Finland,⁴ Garrod and Waterworth,⁵ and others. The pertinent literature has been reviewed by Finland and Garrod⁶ and Kunin and Finland.⁷

The chemotherapeutic advantage of DMCT over TC has been shown to be due to: (1) delayed renal . . . [Full Text PDF of this Article]

Author Affiliations
CHARLOTTESVILLE, VA.

Departments of Preventive Medicine and Medicine, University of Virginia School of Medicine, Charlottesville, Va.

Footnotes
Submitted for publication Oct. 18, 1961.

This work was supported in part by a grant from Lederle Laboratories Division, American Cyanamid Company.

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