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Nephrotic Syndrome After Contact with MercuryA Report of Five Cases, Three After the Use of Ammoniated Mercury Ointment
CARL G. BECKER, M.D.;
E. LOVELL BECKER, M.D.;
JOHN F. MAHER, M.D.;
GEORGE E. SCHREINER, M.D.
Arch Intern Med. 1962;110(2):178-186.
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The nephrotic syndrome after the administration of compounds containing mercury is usually attributed to the toxic action of the metal on the proximal convoluted tubules of the kidney. In a study of the toxic effects of mercury on kidneys of various vertebrate species including man, Edwards found that anatomic alterations were virtually limited to the proximal convoluted tubules.1 The following cases are presented as examples of the nephrotic syndrome due to membranous glomerulonephritis secondary to contact with compounds containing mercury. Three developed after the use of ammoniated mercury ointment.
Report of Cases
CASE 1.—
A 50-year-old man was admitted to The New York Hospital on Feb. 21, 1956, complaining of swollen legs. For 7 months the patient had used ammoniated mercury ointment (2%) for psoriasis involving his scalp, elbows, hands, forearms, and knees. Six weeks prior to admission the patient noticed painless swelling of both ankles. During ensuing weeks, the
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK
Department of Medicine, The New York Hospital-Cornell Medical Center, New York, and the Department of Medicine, Georgetown University School of Medicine, and the Renal and Electrolyte Division, Georgetown University Hospital.
Footnotes
Submitted for publication Dec. 4, 1961.
This work was supported by grants from the New York Heart Association, The Hartford Foundation, and the Georgetown University Kidney Research Fund.
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