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III. Chlorothiazide Alone and in Combination with Other Agents; Preliminary Results

VETERANS ADMINISTRATION COOPERATIVE STUDY ON ANTIHYPERTENSIVE AGENTS

Arch Intern Med. 1962;110(2):230-236.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The previous 2 reports of the Veterans Administration Cooperative Study on Antihypertensive Agents described the results obtained with reserpine, hydralazine, and 3 ganglion blocking drugs.^1,2 The present investigation is concerned with the evaluation of chlorothiazide both alone and in combination with the agents listed above and with cryptenamine, an alkaloid derived from Veratrum viride. Although these latter studies are still in progress, the results seemed of sufficient interest to warrant a preliminary report at this time.

Methods

This investigation used 2 separate protocols for each of 2 different groups of patients. The first (Group A) were untreated cases entering the study for the first time. The second (Group B) were patients who had been under treatment in the cooperative study for at least 1 year,^1,2 after which chlorothiazide was added to the regimens of the patients taking active medications.

The criteria used for selecting patients and for classifying . . . [Full Text PDF of this Article]

Author Affiliations
WASHINGTON, D. C.

Footnotes
Submitted for publication Feb. 26, 1962.

Participants: Mark L. Armstrong, M.D.; Massimo Calabresi, M.D.; Loyal L. Conrad, M.D.; Harold Dodge, M.D.; E. E. Eddelman, M.D.; Edward D. Freis, M.D. (Chairman); Rudolph E. Fremont, M.D.; Walter M. Kirkendall, M.D.; David Littman, M.D.; Clifford G. Pilz, M.D.; Eli A. Ramirez, M.D.; David W. Richardson, M.D., and John H. Williams, Jr., B.A.

These included the following Veterans Administration Hospitals: Birmingham, Ala.; Brooklyn; Chicago West Side; Iowa City; Oklahoma City; Richmond, Va.; San Juan, P.R.; Seattle; Washington, D.C.; West Haven, Conn., and West Roxbury, Mass.

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