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Serum Enzyme Changes During Treatment of Cancer
BERNARD KABAKOW, M.D.;
WILLIAM ANTOPOL, M.D.;
HARRY G. ALBAUM, Ph.D.;
GEORGE BLINICK, M.D.;
LEON GINZBURG, M.D.;
ROBERT YOUNG, B.S.
Arch Intern Med. 1962;110(3):331-338.
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In the last decade, measurement of the levels of certain serum enzymes has come to be an important adjunct to medical practice. Diagnostic significance is attached to the rise of serum acid phosphatase in carcinoma of the prostate, elevation of serum glutamic oxaloacetic transaminase in acute myocardial infarction, the very low levels of cholinesterase in liver disease and high levels in hyperthyroidism, the extremely low level of serum alkaline phosphatase in hypophosphatasia, and changes in serum lactic dehydrogenase activity in certain cases of carcinoma. It has been shown that neither age nor sex influences enzyme levels and that those individuals with nonmalignant tumors (positive controls) do not differ significantly in their enzyme patterns from healthy hospital personnel (negative controls). Patients with various malignant tumors, however, reveal a pattern of change involving a number of serum enzymes which tend to be characteristic of a tumor type.1-3
In another study4
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK
From the Levy Laboratories and Departments of Obstetrics and Gynecology and Surgery, Beth Israel Hospital.
Footnotes
Submitted for publication April 27, 1962, accepted for publication May 29, 1962.
This work has been conducted with the aid of Grants CS-9617 and H-2670 (C4), United States Public Health Service; the Joseph and Helen Yeamans Levy Foundation, and the Saul Singer Foundation.
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