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Treatment by Irradiation of the Spleen

MEIR DJALDETTI, M.D.; ANDRE DE VRIES, M.D.; BETTY LEVIE, M.D.

Arch Intern Med. 1962;110(4):449-455.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Anemia complicating chronic lymphocytic leukemia may have various causes: blood loss, depressed erythropoiesis associated with leukemic infiltration of the bone marrow,^1,2 folic acid deficiency,³ and hemolysis.^1,2 Shortening of red blood cell survival is frequent in chronic lymphocytic leukemia,^4,5 but only in some patients the hemolysis becomes "overt." Severe anemia develops⁴ when the bone marrow is not able to compensate for the accelerated red cell destruction. Then there may be jaundice with elevated indirectreacting serum bilirubin, spherocytosis with increased osmotic fragility, reticulocytosis, a positive Coombs test,⁴ cold or warm agglutinins,^4,6 and leukemic infiltration with erythroid hyperplasia of the bone marrow.

Hemolytic anemia in chronic lymphocytic leukemia may be so severe as to be the main problem requiring intensive treatment. Remission of the hemolytic anemia has followed antileukemic therapy, such as alkylating drugs and spray irradiation⁵ or by corticoid hormones.^2,5,7 Splenectomy has been . . . [Full Text PDF of this Article]

Author Affiliations
PETAH TIKVA, ISRAEL

From the Department of Medicine D, the Hematology Clinic, and the Department of Radiotherapy, Beilinson Hospital of the Labour Sickfund.

Footnotes
Submitted for publication April 2, 1962; accepted June 11.

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