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JEREMY V. COOKE, M.D.; JOHN B. ANDERSON, B.A.; WILLARD S. GAMBLE, M.D.

Arch Intern Med. 1962;110(4):511-515.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A circulating anticoagulant as the cause of a prolonged clotting time was described in 1906 by Weil.¹ An excellent review of this subject has recently appeared in which anticoagulants against Factors I, V, VII, VIII, IX, XI, and XII have been defined.² They have been reported in a variety of diseases including systemic lupus erythematosus, dysproteinemias, liver disease, and penicillin and transfusion reactions as well as generalized skin diseases. Two cases of dermatitis herpetiformis^3,4 and 2 cases of pemphigus vulgaris^5,6 were found to have an anticoagulant against an unspecified factor in the first stage of clotting. A fifth case of a vesiculobullous eruption⁷ was found to have an anticoagulant against tissue thromboplastin. We wish to report a case of generalized bullous dermatitis associated with an anticoagulant against Factor VIII (antihemophilic globulin). We are unaware of any previous case report of a specific anticoagulant against Factor . . . [Full Text PDF of this Article]

Author Affiliations
PORTLAND, MAINE

From the Department of Internal Medicine, Maine Medical Center.

Footnotes
Submitted for publication May 23, 1962; accepted June 26.

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