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PAUL F. FRANK, M.S.; LLOYD F. MILLER, M.D., Dr.P.H.

Arch Intern Med. 1962;110(5):596-605.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Mass administration of penicillin to control streptococcal diseases and their sequelae was first used 10 years ago in the Armed Forces.¹ This practice has been employed with reservation because of the possible development of penicillin-resistant streptococci or the possible emergence and subsequent seeding of populations with penicillin-resistant staphylococci. No confirmed cases of penicillin-resistant Group A streptococci have even been isolated in the 20 years that penicillin has been used as a therapeutic agent, and the likelihood of the appearance of such strains is considered highly improbable. However, the threat of the emergence of penicillin-resistant staphylococci must be considered more seriously in view of staphylococcal epidemics which have been reported in hospital populations in which penicillin had been given extensively.²

No concerted effort has been made to observe the effect of large-scale penicillin administration on penicillin sensitivity of staphylococci in large populations. An opportunity to undertake such an investigation . . . [Full Text PDF of this Article]

Author Affiliations
WASHINGTON, D.C.

Chief, Bacteriology Division (Mr. Frank), and Officer in Charge (Dr. Miller), NAMRU-4.; From Naval Medical Research Unit No. 4, Research Project MR 005.09-1400.1. Bureau of Medicine and Surgery, Navy Department, Washington, D.C.

Footnotes
Presented in part before the First Interscience Conference on Antimicrobial Agents and Chemotherapy, Oct. 31-Nov. 2, 1961, New York.

The opinions and assertions expressed herein are those of the authors and cannot be construed as reflecting the views of the Navy Department or of the Naval Service at large. Usage of commercially available materials cannot be construed as implying endorsement or preference for those products over other similar products available on the market.

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