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Report of 19 Cases and Follow-Up with Corticosteroids

FRANK A. HERBERT, M.D.; BRIGITTE B. NAHMIAS, M.D.; EDWARD A. GAENSLER, M.D.; H. EDWARD MacMAHON, M.D.

Arch Intern Med. 1962;110(5):628-648.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

One of the most interesting and difficult problems of diagnosis and therapy is the dyspneic patient with radiological evidence of diffuse pulmonary infiltration in whom a lung biopsy is eventually obtained which shows an interstitial pneumonitis and fibrosis. The histologic pattern is often similar to that described by Hamman and Rich,¹ but the clinical course is likely to be more chronic than in the original cases. It is now recognized that some systemic diseases such as rheumatoid arthritis, scleroderma, and others occasionally may produce this lung picture. Frequently, however, careful investigation does not reveal any such recognizable disorder.

During the past 10 years we have studied 102 patients who by clinical and roentgenographic criteria appeared to have diffuse interstitial fibrosis of unknown etiology. From this group we have selected 19 patients for presentation here because (1) no possible etiologic factor could be elicited by historic review and by detailed . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Thoracic Services, Massachusetts Memorial Hospital, the Thoracic Surgery Service, Boston City Hospital, Boston University Medical Center, and the Allergy-Pulmonary Service, New England Center Hospital.; Senior Fellow, Allergy-Pulmonary Service, New England Center Hospital (Dr. Herbert); Samuel A. Levine Fellow of the Massachusetts Heart Association, Massachusetts Memorial Hospitals (Dr. Nahmias); Director of Thoracic Services and Associate Professor of Surgery, Boston University School of Medicine (Dr. Gaensler), and Professor of Pathology, Tufts University School of Medicine (Dr. MacMahon).

Footnotes
This study was supported in part by Research Grant H-5933, National Heart Institute, National Institutes of Health, U.S. Public Health Service.

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