 |
|
Minimal Daily Adult Folate Requirement
VICTOR HERBERT, M.D.;
NANCY CUNNEEN;
LOUISE JASKIEL;
CAROLA KAPFF
Arch Intern Med. 1962;110(5):649-652.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
The minimal daily adult folate requirement to sustain normality is unknown. Using a diet1 containing approximately 5µg. of total folate activity for Lactobacillus casei per day, a healthy adult male developed folate deficiency of sufficient degree to produce megaloblastic anemia in 4 1/2 months.2 Three weeks after starting this diet, the serum folate activity for Lactobacillus casei (L. casei) had fallen to below 3 mµg. per milliliter (normal 7 to 16 mµg. per milliliter).3 The first hematologic abnormality, hypersegmentation of the nuclei of the polymorphonuclear leukocytes, was not noted until 7 weeks after starting the diet. Abnormally high formiminoglutamic aciduria after a 20 gm. histidine load did not appear until the subject had been for 3 months on the diet.
In the present study, the minimal daily adult requirement for folic acid was equated with that amount of pteroylglutamic acid required to maintain normality of the earliest
. . . [Full Text PDF of this Article]
Author Affiliations
BOSTON WITH MORE THAN THE TECHNICAL
From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School.
Footnotes
This investigation was supported in part by Research Grants No. A-795 and A-3853 from the National Institutes of Health, U.S. Public Health Service, and in part by a grant from the National Vitamin Foundation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
