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I. Inhibition of Lethal Infections in Chick Embryos Preinfected with Influenza Viruses

MONTO HO, M.D.

Arch Intern Med. 1962;110(5):653-659.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The use of both infective and inactivated viruses as interfering agents¹ and their use in the production of interferons is well known.² Since the discovery of interferon³ and the postulation that it is the chemical intermediary of interference,^4,5,2 the problem as to whether it can quantitatively account for all the interfering activity even in situations in which it is admittedly operative remains.² One such situation is viral interference produced by infective virus in cell cultures or in the intact host.

In studies employing continuous cell lines, it has been found that while cultures of such cells become remarkably resistant to the destructive effects of a cell-killing virus if they are preinfected with a sublethal virus, they are not susceptible to the protective effect of interferons.^6,7,2 Such studies suggest that interferon may not be the sole mediary of this type of viral resistance.

Henderson . . . [Full Text PDF of this Article]

Author Affiliations
PITTSBURGH

From the Department of Epidemiology and Microbiology, Graduate School of Public Health, and Department of Medicine, School of Medicine, University of Pittsburgh.

Footnotes
With the assistance of Mary Kay Breinig, B.S., and Judith Yogodnik, B.S.

Supported by National Institutes of Health Grant E-2953.

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