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Observations on the Cytopathic Effect of Molluscum Suspensions in Vitro

FRANKLIN A. NEVA, M.D.

Arch Intern Med. 1962;110(5):720-725.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The lesion of molluscum contagiosum, like that of the common wart, is a chronic, proliferative process, restricted to the skin epithelium, which presents certain similarities to a localized neoplasm. Considerable information, comprehensively reviewed by Nasemann¹ and others,² exists concerning clinical features, epidemiology, and pathologic aspects of the disease. Evidence for a viral etiology of molluscum contagiosum is based on the successful transmission of infection to man via injected filtrates and on the characteristic pathology of the lesion, namely, the presence of large inclusions or molluscum bodies which contain distinctive elementary bodies when viewed by electron microscopy.³ Final proof of the nature of the etiologic agent, in a manner allowing propagation of the responsible virus in a reproducible and practical fashion, has not yet been established.

Several recent reports have implied the successful in vitro growth of molluscum contagiosum virus in cell cultures. Dourmashkin and Febvre⁴ presented . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

Department of Tropical Public Health, Harvard School of Public Health.

Footnotes
This study was supported (in part) by a grant from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Public Health Service, and (in part) by grants from Parke, Davis and Company and the Lederle Laboratories of American Cyanamid Company.

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