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JAMES CONWAY

Arch Intern Med. 1963;111(2):203-207.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

While it seems likely that the fall in blood pressure produced by the thiazide diuretics is a consequence of their sustained diuretic action, it has not been possible to demonstrate this with certainty, and the mode of action of diuretics in reducing blood pressure remains unexplained. Although there is a reduction in extracellular fluid and plasma volumes over the first few days after the drug is administered,^1-3 these are later restored to their initial levels.^4-7 Furthermore, it has been shown that cardiac output, though initially reduced, returns to normal levels after a period of weeks of continued therapy. Since the blood pressure continues to be reduced, the calculated total peripheral resistance is also reduced, and it has been inferred that the drug affects the blood vessels themselves.⁶ The purpose of this report is to acquire direct evidence by plethysmography for this action on the peripheral blood vessels . . . [Full Text PDF of this Article]

Author Affiliations
From Department of Internal Medicine, University of Michigan Medical Center.; Associate Professor of Internal Medicine and Physiology and Established Investigator of the American Heart Association (Dr. Conway); Research Assistant in the Department of Internal Medicine (Dr. Palmero).

Footnotes
Received for publication Aug. 15, 1962; accepted Sept. 27.

The spironolactone used in this study has been supplied by the G. D. Searle Company, Chicago, and the chlorothiazide by the Merck Sharp and Dohme Company, Pennsylvania.

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