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Progress and Problems blems

ARMAND J. QUICK, M.D.

Arch Intern Med. 1963;111(2):234-239.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The one-stage prothrombin time was intimately associated with the development of oral anticoagulant therapy. As Link has stated: "Through it the hemorrhagic agent of spoiled sweet clover hay was laid out on the table in pure crystalline form." Furthermore, without this simple test, the introduction of bishydroxycoumarin (Dicumarol) into therapy would have been exceedingly hazardous. In the early studies,¹ the increased prothrombin time was regarded as a depression solely of prothrombin, and this assumption was supported by the finding that the 2-stage method of Warner, Brinkhous, and Smith² likewise showed a marked decrease of prothrombin when bishydroxycoumarin was given. The discoveries of Factor V (labile factor) in 1943,³ and of a serum agent (Factor VII) a few years later,^4,5 made it evident that neither method measured prothrombin specifically. It was the one-stage test, however, which has received most of the criticism and been subjected to numerous . . . [Full Text PDF of this Article]

Author Affiliations
MILWAUKEE

From Department of Biochemistry, Marquette University School of Medicine.

Footnotes
Received for publication Sept. 4, 1962. Accepted Oct. 5.

Read before the Joint Meeting on Anticoagulant and Thrombolytic Therapy with the American Heart Association at the 111th Annual Meeting of the American Medical Association, Chicago, June 26, 1962.

Supported by a grant from the American Heart Association.

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