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Hemorrhagic ThrombocythemiaResponse to Busulfan
ALAN T. WEBB, M.D.;
FRANK L. MEYER, M.D.;
EWALD R. LONSER, M.D.
Arch Intern Med. 1963;111(3):280-285.
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Recently there has been increasing recognition of hemorrhagic thrombocythemia as a clinical entity, although its status as a distinct pathological disorder is questioned.1,2 Synonyms are essential thrombocytosis, essential thrombophilia, thrombocythemia hemorrhagica, and hyperthrombotic myelosis. We concur with those who classify this disease with granulocytic leukemia, polycythemia vera, myeloid metaplasia, and myelosclerosis in the general category of "myeloproliferative disorders." There may be no sharp dividing line between the different conditions; indeed, there are known cases of transformation from one form into another.
Characteristic findings include recurrent episodes of hemorrhage and/or thrombosis, megakaryocytic hyperplasia of the marrow, and a striking increase in circulating platelets. Present in some, but not all, patients have been splenomegaly, neutrophilic leukocytosis, erythrocytosis, and a variety of coagulation defects, showing no consistent pattern. The interested reader is referred to several comprehensive reviews of the subject for further details.1,3-7
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Author Affiliations
LOS ANGELES
From the Departments of Pathology and Hematology, Loma Linda University, Loma Linda-Los Angeles.; Assistant Professor of Pathology (Dr. Webb), Clinical Professor of Medicine (Dr. Meyer), and Associate Professor of Pathology, Director of Coagulation Laboratory (Dr. Lonser).
Footnotes
Received for publication Aug. 12, 1962; accepted Oct. 23.
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