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In Vitro Studies and Report of Six Years' Experience with a Prophylactic Program of "Partial Exchange Transfusion"

ROLF ANDERSON, M.D.; MONA CASSELL, B.S.; GRACE L. MULLINAX, B.S.; HUGH CHAPLIN, JR., M.D.

Arch Intern Med. 1963;111(3):286-294.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The protean clinical manifestations of painful sickle-cell crises have been described by many authors,^1-7 but the factors responsible for precipitating the crises remain poorly understood. Many approaches to treatment of crises have been proposed; none has proved regularly effective. Blood transfusions are frequently disappointing in their failure to alter significantly the course of a well-established crisis, even when sufficient blood is given to raise the patient's hemoglobin concentration close to normal. However, despite the lack of immediate clinical improvement following transfusion, the patient frequently remains free from painful crises for 2 to 3 months thereafter. This freedom from crises persists long after the transient relief of anemia by transfusion; presumably the presence of normal donor cells in the patient's circulation exerts a protective effect against precipitation of crises. The nature of this protection is not known, but a likely mechanism is the effect of the transfused cells upon the . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

Fourth-year medical student during work on the investigation (Dr. Anderson), Research Assistants (Miss Cassell and Mrs. Mullinax), and Associate Professor of Medicine and Preventive Medicine (Dr. Chaplin).; From the Barnes Hospital Groups and the Departments of Medicine and Preventive Medicine, Washington University School of Medicine.

Footnotes
Received for publication June 29, 1962; accepted Sept. 21, 1962.

This investigation was supported by Research Grant C-2918 (C1-5) from the National Cancer Institute.

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