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Modified I131-Labeled Rose Bengal Test

J. EDWARD BERK, M.D., D.Sc.; MASAMITSU KAWAGUCHI, M.D.; ALLEN R. SOBLE, M.D.; STANLEY E. GOLDSTEIN, M.D.

Arch Intern Med. 1963;111(3):323-329.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Reports on the use of I¹³¹-labeled rose bengal (RBI¹³¹) to help distinguish between the principal causes for jaundice have not been in agreement. Some observers have found the test to be of value,^1-12 while others have concluded that it was unreliable^13-15 when used for this purpose. Since the methods employed by these investigators were not always the same, the variation in the results obtained may be partially explainable by differences in technique.

In the latter part of 1959, we began a series of studies dealing with hepatic uptake and excretion of RBI¹³¹ in experimental animals and man. A modified test¹⁶ that ultimately evolved from these studies seemed to hold promise as an aid in the differential diagnosis of jaundice.¹⁷ We wish in this communication to present some additional observations and to describe our experience to date with the use of the modified . . . [Full Text PDF of this Article]

Author Affiliations
DETROIT

From the Departments of Medicine, Sinai Hospital of Detroit and Wayne State University College of Medicine.

Footnotes
Received for publication Oct. 22, 1962; accepted Oct. 23.

Read before the Section on Gastroenterology and Proctology at the 111th Annual Meeting of the American Medical Association, Chicago, June 28, 1962.

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