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ANANDA S. PRASAD, M.D., Ph.D.; AUGUST MIALE, JR., M.D.; Z. FARID, M.B., D.T.M. AND H. (ENG.); H. H. SANDSTEAD, M.D.; ARTHUR R. SCHULERT, Ph.D.; WILLIAM J. DARBY, M.D., Ph.D.

Arch Intern Med. 1963;111(4):407-428.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

A syndrome consisting of iron-deficiency anemia, hepatosplenomegaly, dwarfism, and hypogonadism occurring in males in Iran has been described recently by Prasad, Halsted, and Nadimi.^1,2 To account for all the features of the syndrome, it was suggested in the earlier report that these patients were probably zinc deficient. Subsequently, similar patients were studied in Egypt and were found to be zinc deficient.¹⁶ The purpose of this paper is to present results of extensive biochemical studies in such patients, to characterize more fully the nature of this syndrome, and to describe five cases in detail.

Clinical Material and Methods

Patients were selected from villages near Cairo. The ages, verified by birth certificate in each case, ranged from 12 to 19 years. None of them had any evidence of chronic infections such as tuberculosis, syphilis, or brucellosis. A detailed history and physical examination were carried out on each patient on . . . [Full Text PDF of this Article]

Author Affiliations
NASHVILLE, TENN.; CAIRO, U.A.R.; NASHVILLE, TENN.

From the Department of Medicine and Biochemistry and the Division of Nutrition, Vanderbilt University, Nashville, Tenn., and Medical Department, U.S. Naval Medical Research Unit, No. 3, Cairo, U.A.R.; Assistant Professor of Medicine in Nutrition, Vanderbilt University, Nashville, present address: NAMRU-3, c/o American Embassy, Cairo (Dr. Prasad); Lieutenant Commander, Medical Corps, United States Navy, and Head, Medical Department, NAMRU-3, Cairo (Dr. Miale); Director, Clinical Research Division, NAMRU-3, Cairo (Dr. Farid); Senior Assistant Surgeon, United States Public Health Service, Medical Department, NAMRU-3, Cairo (Dr. Sandstead); Assistant Professor of Biochemistry in Nutrition, Vanderbilt University, Nashville, present address: NAMRU-3, c/o American Embassy, Cairo (Dr. Schulert); Professor and Head, Department of Biochemistry and Division of Nutrition, Vanderbilt University, Nashville (Dr. Darby).

Footnotes
Received for publication Nov. 9, 1962; accepted Nov. 27.

This research was supported by Research Contract Nonr 2149 from the Navy Department Office of Naval Research to Vanderbilt University and a grant from the National Institutes of Health under Public Law 480.

The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department, the Naval Service at large, or the Egyptian Ministry of Public Health.

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