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I. N. SPORN, M.D.; R. G. LANCESTREMERE, M.D.; C. A. VAAMONDE, M.D.; SOLOMON PAPPER, M.D.

Arch Intern Med. 1963;111(4):439-442.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is well established that patients with essential hypertension have an exaggerated natriuretic response to the rapid intravenous administration of sodium.^1-4 While the mechanisms responsible for the enhanced natriuresis of essential hypertension remain unknown, a defect in the renal tubular capacity to conserve sodium has been proposed as a possible explanation.⁵

Most of the available literature relating to salt conservation in patients with hypertension is concerned with the response to chronic salt restriction. The experiments of Black⁶ and Renwick⁷ seem to offer conclusive proof that the hypertensive patient conserves sodium normally under these conditions. However, these chronic experiments may not be applicable to the problem of exaggerated natriuresis, because the latter occurs only in response to an acute stimulus for sodium excretion. The enhanced natriuretic response is a transient one and is followed by a rate of sodium excretion comparable to that of the normotensive subject. . . . [Full Text PDF of this Article]

Author Affiliations
RICHMOND, VA.

Postdoctoral Research Fellow of the National Heart Institute (Dr. Sporn); work done during the tenure of a Research Fellowship of the American Heart Association (Dr. Lancestremere); Research Fellow of the University of Buenos Aires, Argentina (Dr. Vaamonde); present address: Professor and Chairman, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, N. Mex. (Dr. Papper).; From the Department of Medicine, Medical College of Virginia.

Footnotes
Received for publication Nov. 30, 1962; accepted Jan. 8, 1963.

This investigation was supported by a research grant (PHS No. N.I.H.-H-5162) from the National Heart Institute, Public Health Service.

This material has appeared in part in abstract form in Clinical Research 10:21, 1962.

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