This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (27)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Their Sequential Occurrence in the Same Patient

ROBERT H. SCHWAB, M.D; JOSEPH K. PERLOFF, M.D.; RICHARD L. PORUS, M.D.

Arch Intern Med. 1963;111(4):465-470.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Chlorothiazide has been a drug of undisputed value both as a nonmercurial diuretic¹ and as an adjunct in the treatment of systemic hypertension.² Side-effects, though uncommon, should nevertheless be recognized in view of the frequent use of this agent and in view of the impression that its use is relatively free of untoward sequelae. In the past few years reported complications of chlorothiazide administration have included thrombocytopenia,³ agranulocytosis,⁴ jaundice,⁵ photosensitivity,⁶ yellow vision,⁷ skin eruptions,⁸ hypokalemia,^9,10 pancreatitis,^{11, 12A,12B} pancreatic atrophy,¹³ and hyperpyruvicacidemia.¹⁴ Of particular interest have been two additional complications: ( 1 ) hyperuricemia^15,16—alone or with clinical manifestations of gout,^17-20 and (2) hyperglycemia—either in previously nondiabetic subjects or in otherwise well-stabilized diabetics.^21-28 We have recently had an opportunity to observe a patient who, after receiving chlorothiazide continually for four years, developed, in sequence, hyperuricemia with acute . . . [Full Text PDF of this Article]

Author Affiliations
WASHINGTON, D.C.

From the Department of Medicine, Georgetown University School of Medicine, Division of Cardiology, Georgetown University Hospital.

Footnotes
Received for publication Oct. 15, 1962; accepted Dec. 7.

Supported in part by grants from the U.S. Public Health Service, National Institutes of Health, Bethesda, Md., (HSG-14,009), and the Sean O'Kelly Fund.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?