 |
|
Malignant Degeneration and Metastasis in Peutz-Jeghers Syndrome
JAMES L. ACHORD, M.D.;
HERBERT D. PROCTOR, M.D.
Arch Intern Med. 1963;111(4):498-502.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
Since Peutz in 19211 recognized the hereditary nature of gastrointestinal polyposis associated with oral pigmentation and its reemphasis by Jeghers in 1949,2 the syndrome of Peutz-Jeghers has become a well-documented clinical entity. Several thorough reviews have appeared on the clinical features of this syndrome.2,4-7 It is not our intention here to reiterate these signs and symptoms. A facet still unsettled, however, is the question of whether "malignant" changes as previously described in approximately 20% of the cases8 are true malignancies or developmental anomalies as suggested by Bartholomew et al.5 A survey of the English language literature through reviews and individual case reports still fails to reveal a single, well-documented case of metastasis or death directly attributable to malignant degeneration of a polyp at any site in the Peutz-Jeghers syndrome. The following case is, to our knowledge, the first documented instance of such an occurrence.
Report
. . . [Full Text PDF of this Article]
Author Affiliations
ATLANTA
From the Department of Medicine, Emory University School of Medicine, and the Medical Service, Grady Memorial Hospital.; Instructor in Medicine, Emory University School of Medicine (Dr. Achord); Senior Assistant Resident in Medicine, Grady Memorial Hospital (Dr. Proctor).
Footnotes
Received for publication July 26, 1962; accepted Sept. 13.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
