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BURTON D. COHEN, M.D.; RICHARD S. BENUA, M.D.; RULON W. RAWSON, M.D.

Arch Intern Med. 1963;111(5):641-646.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Von Basedow¹ in 1840, recording one of the earliest descriptions of exophthalmic goiter, made note of an interesting physical finding: "The legs became, from the lower third of the thighs to the extremities, very fat, however not edematous, the cellular tissue seemed rather brawny, on pressure leaves no dent and after acupuncture produces no falling out of serum." Sollier² in 1891 reported a similar finding in association with thyrotoxicosis which he termed Basedow's disease with myxedema.

In 1942 Trotter and Eden³ reviewed 73 cases of pretibial myxedema and added 4 of their own; in every instance the lesions were confined to the legs and associated with a history of hyperthyroidism. A review of the English language reports since 1942 brings the total reported cases to 317.^4-54

In the instance reported by Sunseri⁴ the lesions were noted to involve both legs and the lower abdomen . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Medicine, Memorial Center for Cancer and Allied Diseases.; Instructor in Medicine (Dr. Cohen); Assistant Professor (Dr. Benua); Professor of Medicine (Dr. Rawson); Cornell University Medical College.

Footnotes
Received for publication Aug. 23, 1962; accepted Oct. 23.

Present address of Dr. Cohen: The Bronx Hospital, Bronx, N.Y.

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