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II. Clinical Studies, With Emphasis on the Rate of Disappearance of Staphylococci From Various Lesions

RICHARD G. WEBER, MD; JANET SCHUMACHER, AB; MORTON HAMBURGER, MD

Arch Intern Med. 1963;111(6):756-761.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The proved effectiveness of methicillin in infections caused by penicillinase-producing staphylococci has stimulated interest in the development of a similar antibiotic which could be administered orally. One of these, oxacillin, has already demonstrated its usefulness.^1,2 Another, sodium diphenicillin (sodium 2-biphenylylpenicillin), has recently been made available for clinical trials after preliminary study in the laboratory.³ We have treated 28 infections caused by penicillinase-producing staphylococci, one caused by Staphylococcus albus, and one case of endocarditis caused by a β-hemolytic Streptococcus with this compound, and have in addition carried out a detailed study of the rate of disappearance of staphylococci from the lesions of the treated patients. It is the purpose of this paper to report these studies.

Materials and Methods

Case Material.—

The 30 cases in this series were chosen because they harbored serious infections. All patients were seen daily by a member of the Infactious Disease Service. Only . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI

From the Infectious Disease Laboratory, Department of Medicine, University of Cincinnati College of Medicine and the Cincinnati General Hospital.

Footnotes
Received for publication Nov 28, 1962; accepted Nov 30.

This study was supported by USPHS grant E-3523; the Smith Kline & French Laboratories, Philadelphia, and the Lederle Laboratories Division, American Cyanimid Co.

Sodium diphenicillin was supplied through the courtesy of Mr. Donald B. Cheatham, Jr., of the Smith Kline & French Laboratories.

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