This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (10)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

RICHARD H. PARKER, MD; VINCENT S. W. CHIU, MD; PAUL D. HOEPRICH, MD

Arch Intern Med. 1963;111(6):799-808.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since the introduction of antibacterial agents, serious infections due to enteric pathogens have occurred with increasing frequency.¹ Because these microorganisms are quite often resistant to the commonly employed, safe antibacterial agents, therapy frequently requires the use of agents with significant potential for serious human toxicity. Specifically, the treatment of infections due to Salmonella species other than Salmonella typhosa are frequently not cured with chloramphenicol²; Proteus mirabilis is resistant to the clinically usable concentrations of most antibiotics with the exception that large doses of penicillin G may be effective in some circumstances.³ Recently, Noall et al⁴ emphasized the difficulty in attaining success in treatment of Proteus infections.

Approximately ten years ago the antibiotic penicillin N (cephalosporin N) was isolated and identified as D-4-amino-4-carboxy-n-butyl penicillin. When compared with penicillin G (benzyl penicillin), this penicillin was not very active as an inhibitor of Gram-positive microorganisms. However, it was surprisingly . . . [Full Text PDF of this Article]

Author Affiliations
SALT LAKE CITY

Research Fellow, Division of Infectious Diseases, Department of Internal Medicine, University of Utah College of Medicine, presently Chief Resident, Medical Service, University of Utah Affiliated Hospitals (Dr. Parker); Instructor in Medicine, University of Utah College of Medicine, formerly, Research Fellow, Division of Infectious Diseases, Department of Internal Medicine, University of Utah College of Medicine (Dr. Chiu); Associate Professor of Medicine and Chief, Division of Infectious Diseases, Department of Internal Medicine, University of Utah College of Medicine (Dr. Hoeprich).; Division of Infectious Diseases of the Department of Internal Medicine, University of Utah College of Medicine and the Salt Lake County General Hospital.

Footnotes
Received for publication Nov 8, 1962; accepted Dec 18.

Supported in part by grants 2E-39 and E-1792 from the National Institutes of Allergy and Infectious Diseases, US Public Health Service, Department of Health, Education, and Welfare, Bethesda, Md.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?