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Report of a Case Due to Thorium

HAROLD L. RAKOV, MD; T. R. SMALLDON, MD; HERBERT DERMAN, MD

Arch Intern Med. 1963;112(2):173-178.

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Introduction

Calamitous effects of new drugs have been emphasized in the current literature, with the withdrawal of many such as triparanol (MER-29) and etryptamine acetate (Monase). Fortunately only a few pregnant women were exposed to the mutilating effects on their offspring by thalidomide, but this was true only because the US Food and Drug Administration was adamant in considering the drug unsafe. Similarly the Council on Pharmacy and Chemistry of the American Medical Association in 1932¹ condemned the intravenous use of Thorotrast (thorium dioxide sol) for roentgen visualization of the liver and spleen because "the period of observation on patients and animals since its introduction was insufficient to rule out ensuing necrotic and/or malignant changes." The following case substantiates the wisdom of their judgment on a preparation initially benign but insidiously lethal.

Report of Case

A retired white prison guard, 65 years of age, was referred to the . . . [Full Text PDF of this Article]

Author Affiliations
KINGSTON, NY

Director of Medicine (Dr. Rakov), Roentgenologoist (Dr. Smalldon), Pathologist (Dr. Derman), Kingston Hospital.

Footnotes
Received for publication Oct 8, 1962; accepted Feb 26, 1963.

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