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A New Technique and Rationale for Treatment

JOSE RAMIREZ-R., MD; ROBERT B. SCHULTZ, MD; ROBERT E. DUTTON, MD

Arch Intern Med. 1963;112(3):419-431.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since the description by Rosen, Castleman, and Liebow¹ of pulmonary alveolar proteinosis, various empiric methods of treatment have been proposed. Clinical improvement was noted in 3 of 21 cases during therapy with corticosteroids ^1-10 and radiographic improvement on two ^11,12 of seven patients ^9,11,12,14 treated with potassium iodide. One of the two patients ¹² who improved while receiving oral iodides also received streptokinase-streptodornase by aerosol. Aerosol therapy has been associated with clinical and rediographic improvement in three other cases—one received streptokinase-streptodornase ¹⁵ and two trypsin.^8,9 One patient ⁸ tolerated trypsin aerosol therapy for only six days, but the oral intake of 400 units of trypsin-chymotrypsin daily was associated with progressive clearing of the chest x-ray film. The efficacy of these regimens is still in question, however, since spontaneous remissions have been reported¹ and clinical observations in this rare disease have been, by necessity, limited and uncontrolled.

This communication . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

Assistant Chief, Medical Service, Veterans Administration Hospital, and Assistant in Medicine, The Johns Hopkins University School of Medicine (Dr. Ramírez-R.); Associate Professor of Pathology, University of Maryland School of Medicine (Dr. Schultz); Clinical Investigator, Veterans Administration Hospital, and Instructor in Environmental Medicine, The Johns Hopkins University School of Hygiene and Public Health (Dr. Dutton).

Footnotes
Received for publication Jan 10, 1963; accepted Feb 20.

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