This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (4)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

With Leucine-Induced Hypoglycemia

JOHN BUSE, MD; J. NEIL MARSHALL, MD; RANDOLPH BRADHAM, MD; HARVEY OBERMAN, MD; MARIA G. BUSE, MD

Arch Intern Med. 1963;112(4):584-588.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Cochrane, Payne, Simpkiss, and Wolff first described in 1956 ¹ a type of hypoglycemia in infants which was precipitated or aggravated by feedings containing L-leucine. Approximately 60 children with this familial disorder have been reported.² Weisenfeld and Goldner recently reviewed the incidence of L-leucine sensitivity in adults.³ They found five instances of leucine-induced hypoglycemia in parents of L-leucine-sensitive children. All were asymptomatic as adults, although three gave a history of childhood convulsions. Seven adults with L-leucine-sensitive hypoglycemia but without a family history of the disease have been reported.^3-7 These adults had adenomas or carcinomas of the islets of Langerhans.

To our knowledge this report describes the eighth patient with organic hyperinsulinism in whom hypoglycemia was induced by the oral administration of L-leucine. Her clinical history initially suggested a focal brain lesion.

Report of a Case

First Admission (May 31, 1962).

—A 51-year-old, right-handed, white . . . [Full Text PDF of this Article]

Author Affiliations
CHARLESTON, SC

Assistant Professor of Medicine (Dr. J. Buse); Associate in Neurology (Dr. Marshall); Associate Professor of Surgery (Dr. Bradham); Senior Resident in Medicine (Dr. Oberman); Assistant Professor of Research Medicine (Dr. M. Buse).; From the departments of medicine and surgery of the Medical College of South Carolina.

Footnotes
Received for ublication Jan 16, 1962; accepted April 8.

This work was supported in part by grants 2A-5078 (C6) and AM-02001-05, National Institute of Arthritis and Metabolic Diseases.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?