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A Clinical and Pathological Study

MAURICE A. PEARL, MD; ROBERT R. BURCH, MD; ENRIQUE CARVAJAL, MD; BRIAN H. McCRACKEN, MD; HANNAH B. WOODY, MD; WILLIAM H. STERNBERG, MD

Arch Intern Med. 1963;112(5):716-726.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The nephrotic syndrome is a complex clinical disorder, characterized by massive proteinuria, hypoalbuminemia, hyperlipemia, and edema. The syndrome can be caused by various conditions and is not a distinct disease entity. It is observed in generalized diseases which affect the kidneys, such as diabetes mellitus, systemic lupus erythematosus, amyloidosis; after exposure to certain drugs or heavy metals; from interference with the renal circulation, as in renal vein thrombosis, or constrictive pericarditis; and it also occurs due to intrinsic renal disease, the so-called primary form of the nephrotic syndrome.^1-9 In the primary form of the nephrotic syndrome, the pathological changes as revealed by percutaneous renal biopsies are multiple and variable. Clinically, the course of the illness and the response to therapy are also variable, and a question which remains to be answered is whether the primary form of the nephrotic syndrome represents different diseases or different stages of one disease. . . . [Full Text PDF of this Article]

Author Affiliations
NEW ORLEANS

From the Renal Clinic of the Department of Medicine and Pediatrics and the Department of Pathology, Tulane University School of Medicine and Charity Hospital of Louisiana.

Footnotes
Received for publication May 21, 1963; accepted May 27.

This investigation was carried out during the tenure of a postdoctoral research fellowship from the National Heart Institute (Dr. Pearl); portion of work performed during tenure of Eli Lilly Foundation Fellowship (Dr. Carvajal).

This work supported in part by grant AM-05911 from the National Institutes of Health.

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