 |
|
Study of Experimental Staphylococcal Endocarditis in DogsIV. Distribution of Penicillin-G-Sensitive and -Resistant Staphylococci in Tissues, Following Inoculation of Mixtures of the Two Variants
MORTON HAMBURGER, MD;
NOVELLA ANN SCHAFER, MD;
LOIS W. AVERY, AB
Arch Intern Med. 1963;112(5):755-759.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
Introduction
The recovery of penicillin-G-sensitive variants of a resistant staphylococcus from the blood and tissues of two dogs with experimental endocarditis, infected with the resistant parent strain, has been previously reported.1 In one dog the number of sensitive variants recovered from the blood stream gradually increased during the infection in proportion to the resistant ones for reasons which were not apparent; in the other they were found in small numbers only at autopsy. These sensitive variants have retained their penicillin sensitivity after five years' passage through penicillin-free broth and after passage through untreated dogs and dogs treated with tetracycline.2
In view of widespread interest in ecological relationships between antibiotic-sensitive and antibiotic-resistant bacteria, the finding of these penicillin-sensitive mutants in vivo provided an opportunity for artificially mixing two closely related variants of the same strain and studying their fate when inoculated into dogs. We have accordingly injected mixtures of
. . . [Full Text PDF of this Article]
Author Affiliations
CINCINNATI
From the Infectious Disease Laboratory, Department of Medicine, University of Cincinnati College of Medicine, and the Cincinnati General Hospital.
Footnotes
Received for publication Feb 25, 1963; accepted Feb 28.
This investigation was supported by USPHS grants H-1931 and E-3523 and the Lederle Laboratories, Division of American Cyanamid Company.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
