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With Special Reference to Ammonia and Keto Acid Metabolism

DARAB K. DASTUR, MD; RAJESWARI SESHADRI, MSc; V. R. TALAGERI, MSc

Arch Intern Med. 1963;112(6):899-916.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the century which has elapsed since the classical clinical description of Frerichs ¹ of the neurological and mental changes in advanced liver failure, and especially since the studies in Pavlov's laboratory on meat intoxication in dogs with an Eck fistula,² and the observation of a rise in blood ammonia in man by Kirk ³ and several others, ammonia and related amino acids and metabolites have held the center of the field in investigations attempting to elucidate the pathogenesis of hepatic coma. Subsequently Bessman et al⁴ showed an increased uptake of ammonia by the brain, and Fazekas et al ⁵ demonstrated a reduced cerebral oxygen consumption in hepatic coma. Critical and detailed reviews on this subject have come recently from Sherlock,⁶ Chalmers,⁷ Walshe,⁸ Dastur,⁹ and Seshadri.¹⁰

The main purpose of the present investigation was to reassess the role of ammonia and amino acids and of certain keto acids . . . [Full Text PDF of this Article]

Author Affiliations
BOMBAY, INDIA

From the Neuropathology Unit of the Indian Council of Medical Research, Laboratories of the Indian Cancer Research Centre and Tata Memorial Hospital.

Footnotes
Received for publication Feb 28, 1963; accepted May 6.

Some aspects of this investigation were presented at the Symposium on Neurological Disorders in Liver Disease at the VIIth International Congress of Neurology, Rome, September, 1961, and at the 1st Asian and Oceanian Congress of Neurology, Tokyo, October, 1962.

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