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A. P. DOYLE, MD; S. P. BALCERZAK, MD; C. L. WELLS, MD; J. O. CRITTENDEN, MD

Arch Intern Med. 1963;112(6):940-946.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Pulmonary alveolar proteinosis is a disorder of obscure and possibly diverse causes. Clinical features frequently observed have been recurrent febrile episodes of "pneumonia," paucity of physical signs on auscultation and percussion, and a disparity between dramatic radiographic findings and relatively little incapacity.¹ Several individuals have been asymptomatic at the time of discovery of their disease on routine chest roentgenogram. There may be spontaneous regression of even extensive infiltrates, a circumstance which makes evaluation of therapeutic programs difficult. The duration of the disease may be longer than ten years, or there may be progression to a fatal issue within six months of the apparent onset. In many of the autopsied cases complicating fungal infections have been found.

Among the 80-odd cases in the literature are three which were associated with blood dyscrasias. Two additional cases of pulmonary alveolar proteinosis with hematologic disease form the subject of the present report. . . . [Full Text PDF of this Article]

Author Affiliations
PITTSBURGH

From the medical and laboratory services, Veterans Administration Hospital: the Department of Medicine, University of Pittsburgh: and the Laboratory Service, Presbyterian-University Hospital.

Footnotes
Received for publication March 18, 1963; accepted May 10.

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