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Report of a Case Treated With Peritoneal Dialysis

LEWIS R. WEINTRAUB, MD; JOHN A. PENNER, MD; MURIEL C. MEYERS, MD

Arch Intern Med. 1964;113(1):111-114.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Hyperuricemia and uricosuria are frequently encountered in patients with chronic granulocytic leukemia and the acute leukemias.¹ This is believed to be due to an increase in nucleic acid metabolism. Destruction of the leukemic cells and the interference with nucleic acid synthesis following the use of various therapeutic agents (x-ray, alkylating agents, cortisone, and antimetabolites) further augment the production of uric acid.

The occurrence of renal failure secondary to intra- and extrarenal crystallization of uric acid with resultant urinary obstruction has been observed during the course of therapy for leukemia.^2,3 To reduce the precipitation of uric acid crystals the maintenance of a high urinary output and the alkalinization of the urine have been advocated.

We wish to report a case of acute uric acid nephropathy with renal failure which occurred during the treatment of a patient for acute granulocytic leukemia. Peritoneal dialysis was used successfully to reduce azotemia . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH

Footnotes
Received for publication Jan 15, 1963; accepted July 15.

Formerly Resident, Department of Internal Medicine, The University of Michigan, Ann Arbor; present address: Department of Hematology, Walter Reed Army Institute of Research, Washington, DC (Dr. Weintraub); Established Investigator, American Heart Association, Assistant Professor of Internal Medicine and Research Associate, Simpson Memorial Institute, The University of Michigan, Ann Arbor (Dr. Penner); Professor of Internal Medicine and Associate Director, Simpson Memorial Institute, The University of Michigan, Ann Arbor (Dr. Meyers).

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